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Thursday, August 6, 2020 | History

7 edition of Membrane Lipid Signaling in Aging and Age-Related Disease (Advances in Cell Aging and Gerontology) found in the catalog.

Membrane Lipid Signaling in Aging and Age-Related Disease (Advances in Cell Aging and Gerontology)

by M.P. Mattson

  • 120 Want to read
  • 35 Currently reading

Published by Elsevier Science .
Written in English


The Physical Object
Number of Pages236
ID Numbers
Open LibraryOL7530668M
ISBN 100444512977
ISBN 109780444512970

Aging is an inevitable time-dependent decline of various physiological functions that finally leads to death. Progressive protein damage and aggregation have been proposed as the root cause of imbalance in regulatory processes and risk factors for aging and neurodegenerative diseases. Oxygen is a modulator of aging. In Membrane Lipid Signaling in Aging and Age-Related Disease (pp. ). (Advances in Cell Aging and Gerontology; Vol. 12). (Advances in Cell Aging and Gerontology; Vol. 12). Cholesterol, β-amyloid, and Alzheimer's : Miguel A. Pappolla, Suzana Petanceska, Lawrence Refolo, Nicolas G. Bazan.

  These microdomains are resistant to detergent solubilization at 4°C and have been designated “detergent-resistant plasma membrane domains” or “lipid rafts” (LR) [ 8 ]. This article will discuss the alterations in T cell signaling with aging in relation to LR functions and the role of cholesterol in this by: cell death and its contribution to aging and age-related diseases has been intensively investigated (3, 20). However, little is known about the protective signaling cascades that are activat-ed by oxidative stress under normal metabolic conditions. These signaling pathways are Cited by:

  They represent a platform for protein-lipid and protein–protein interactions and for cellular signaling events. In addition to their normal functions, including membrane trafficking, ligand binding (including viruses), axonal development and maintenance of synaptic integrity, rafts have also been implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer’s disease Cited by: cess of signal transduction. Recent findings In particular, the constituency of membrane lipids can regulate how proteins with SH2 domains and molecules like K-Ras expose their catalytic domains to the cytosol and interact with effectors and second messengers. Recent reports have also shown that the degree of saturation of phospholipids can reduce the activation of certain G-protein-coupled.


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Membrane Lipid Signaling in Aging and Age-Related Disease (Advances in Cell Aging and Gerontology) by M.P. Mattson Download PDF EPUB FB2

Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters.

Read the latest chapters of Advances in Cell Aging and Gerontology atElsevier’s leading platform of peer-reviewed scholarly literature Membrane Lipid Signaling in Aging and Age-Related Disease. Mark P. Mattson. Vol Pages () Download full volume.

select article Cellular cholesterol, membrane. The lipids of cellular membranes not only serve roles in controlling structure and fluidity of membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function.

This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease. Lipid rafts-discrete regions in cell membranes that are rich in cholesterol and sphingolipids-are emerging not only as pivotal command and control centers for cellular signaling processes, but also as central to a wide array of human diseases, including immune disorders, diabetes, cardiovascular disease.

signaling effects (Sunshine & Iruela‐Arispe, ). Lipids are perhaps the most well‐known for the paramount roles they play in both the storage and mobilization of energy. Although lipids have been traditionally treated as detrimen‐ tal and as simply associated with age‐related diseases, numerousCited by: 2.

Targeting a critical enzyme involved in the metabolism of cellular membrane molecules could help treat age-related neurodegenerative diseases. Aging Author: Min Hee Park, Hee Kyung Jin, Jae-sung Bae.

Membrane Biomechanics, Vol the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on Lipid bilayers: phase behavior and mechanics, Molecular mechanisms of cell membrane structure modification by omega-3 fatty acids, Mechanical properties of magnetoliposomes.

Moreover, changes in the plasma membrane signaling domains of aged lymphocytes may be a result of other age-related processes including macromolecular damage from reactive oxygen species, post-translational modifications of protein and lipid moieties such as glycosylation, and changes in synthesis and turnover of plasma membrane components such.

Peroxisomal Dysfunction in Age-Related Diseases aging-related diseases, including diabetes, neurodegenerative disorders, and cancer[5], involved in the organization of cholesterol-rich membrane regions known as detergent-resistant microdomains, which have been implicated in cellular signaling [16].

Advances in Cell Aging and Gerontology, Volume Membrane Lipid Signaling in Aging and Age-Related Disease avg rating — 0 ratings — published — 4 editions4/5(5).

The role of lipid metabolism in aging, lifespan regulation, and age-related disease Due to the sheer amount of time and cost required to validate a study in humans, the bulk of our aging and lifespan data come from shorter-lived yeast, worms, flies, and rodents.

Lipid signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission) because lipids can freely diffuse through membranes (see osmosis.) One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized "on.

Membrane/lipid rafts and neurobiology: Age-related changes in membrane lipids and loss of neuronal function Article (PDF Available) in The Journal of Physiology (16) August with Reads. Age-related alterations in T cell signaling. There are several age-associated alterations in these T cell activation pathways, as observed in experimental animals [23,24] and humans.

The most important changes occur in CD4 + T cells resulting in the decreased production of Cited by: Lipid peroxidation is a process that takes place along the cell membrane by effect of free radical oxidation of polyunsaturated fatty acids, and as a consequence of this chain reaction, it results in the formation of reactive products with toxic effects (e.g., malondialdehyde (MDA) or Author: Carlos Fernández‐Moriano, Elena González‐Burgos, Maria Pilar Gómez‐Serranillos.

Advances in Cell Aging and Gerontology, Volume Membrane Lipid Signaling in Aging and Age-Related Disease by Mark P. Mattson avg rating — 0 ratings — published — 4 editions.

Membrane Lipid Replacement supplements with or without other mitochondrial supplements can significantly diminish fatigue and other mitochondria-associated symptoms found in aging, cancer and chronic : Garth L. Nicolson, Gonzalo Ferreira, Robert Settineri, Rita R.

Ellithorpe, Paul Breeding, Michael E. The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function.

«Back to Membrane Lipid Signaling in Aging and Age-Related Disease. Find in a Library Find Membrane Lipid. Membrane lipids are “amphipathic,” with a polar end anchoring the lipid to the aqueous interface and a long hydrophobic segment that forms the oily membrane interior.

In human cells, there are more than major lipid species and countless minor lipids. There have been several attempts to classify lipids. Reducing the elevated age-related autophagosome formation might help to maintain the levels of cellular lipids that are essential for repair of cellular membrane structures, the lipid composition.

Until recently, it was unknown if such trait of mitochondrial functionality as the composition of mitochondrial membrane lipids can influence aging in yeast. Our recent studies have revealed that lithocholic bile acid (LCA) can delay the onset and decrease the Cited by: 3.Lipids in the brain are major components playing structural functions as well as physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic transmission, signal transduction, membrane compartmentalization, and regulation of gene expression.

Determination of brain lipid composition may provide not only essential information about normal brain functioning, but also Cited by: 2.How lipids impact longevity, and how lipid metabolism is regulated during aging, is just beginning to be unraveled.

review describes recent advances in the regulation and role of lipids in longevity, focusing on the interaction between lipid metabolism and chromatin states in aging and age-related Size: 2MB.